查看完整版本: 消费者团体要求政府禁用Avandia

消费者团体要求政府禁用Avandia

[b]30-OCT-2008[/b]
[b][size=18pt]Consumer group asksgovernment to ban Avandia[/size][/b][b][size=18pt][/size][/b]
[font=SimSun][size=18pt]消费者团体要求政府禁用[/size][/font][b][size=18pt]Avandia[/size][/b][b][size=18pt][/size][/b]

[align=right]Microjuh[font=SimSun]译[/font][/align]
WASHINGTON- The government should ban the diabetes drug Avandia because of a wide varietyof life-threatening risks, including heart and liver damage, a consumer groupsaid Thursday.

[font=SimSun]华盛顿－消费者团体星期四表示，由于广泛而多种威胁生命的风险，包括心脏和肝脏的损害，政府应该禁用[/font]Avandia[font=SimSun]这种糖尿病用药。[/font]

Theconsumer group, Public Citizen, filed a petition with the Food and DrugAdministration to have Avandia taken off the market.

[font=SimSun]名为公共市民的消费者团体向美国食品暨药物管理局递交了一份请愿书，希望能令[/font]Avandia[font=SimSun]退出市场。[/font]

Itwas the second setback in as many weeks for the GlaxoSmithKline medication,which at one time had shown great promise in reducing the blood sugar levels ofpeople with Type 2 diabetes. Last week, the American Diabetes Association and aEuropean counterpart jointly released updated treatment guidelines for doctorsthat pointedly recommended against using Avandia.
[font=SimSun]对[/font][font=SimSun]葛兰素史克药厂的[/font]Avandia[font=SimSun]来说，这是几星期来所遭到的第二次挫败，葛兰素史克药厂的[/font]Avandia[font=SimSun]曾经一度被认为是第[/font]2[font=SimSun]型糖尿病人降低血糖的极大希望。上周，美国糖尿病学会和欧洲的糖尿病机构在联合发表了给医师的更新治疗指南中，强调地建议反对使用[/font]Avandia[font=SimSun]。[/font]
"TheFDA is in possession of clear, unequivocal evidence that (Avandia) causes awide variety of toxicities," Public Citizen said in its petition."Many of these are life-threatening, such as heart attacks, heart failure(and) liver failure."
[font=SimSun]〝美国食品暨药物管理局拥有清晰、明确的证据显示[/font]Avandia[font=SimSun]导致了广泛多种的毒性〞，公共市民消费者团体在他们的请愿书中写道，〝后些毒性中，有许多是有生命威胁的，如心脏病、心脏衰竭以及肝衰竭。〞[/font]

TheFDA said it will "carefully review" the petition, and it continues tomonitor Avandia's safety record.

[font=SimSun]美国食品暨药物管理局表示会〝仔细谨慎地检视〞该请愿书，并持续监控[/font]Avandia[font=SimSun]的安全记录。[/font]

Avandia'sheart risks were brought to light two years ago in a medical journal articlethat reported a 43 percent higher risk of heart attacks among Avandia patientswhen compared with those taking other diabetes drugs. Although scientists arestill debating a link between the drug and heart attacks, concerns about themedical evidence led to stronger warnings.
Avandia[font=SimSun]导致心脏风险是在[/font]2[font=SimSun]年前的医学期刊的论文中被揭露，该论文报告指出相较于服用其它降血糖药的糖尿病人，服用[/font]Avandia[font=SimSun]的病人引起心脏病的风险高了[/font]43%[font=SimSun]。尽管科学家对[/font]Avandia[font=SimSun]和心脏病之间的关联仍持续争论，对这个医学证据的关注引起了强烈的警示。[/font]

As aresult, Avandia use dropped sharply but about a million U.S. patients stilltake it.

[font=SimSun]结果，[/font]Avandia[font=SimSun]的使用急速下滑，但仍有大约一百万的美国糖尿病人在服用。[/font]

PublicCitizen said its own research found 14 cases of liver failure associated withAvandia, 12 of which led to death. The petition also said Avandia predisposessome patients to eye problems, anemia and bone fractures.

[font=SimSun]公共公民表示根据它们自己的研究发现有[/font]14[font=SimSun]例肝衰竭与[/font]Avandia[font=SimSun]有关，而[/font]12[font=SimSun]例导致死亡。请愿书也表示[/font]Avandia[font=SimSun]让某些糖尿病人容易出现眼睛的问题、贫血和骨折。[/font]

Glaxo,in a statement, said it does not believe Avandia causes liver failure. Thecompany said its own data shows the drug has a good safety record when it comesto liver problems. The company said the data on heart attacks is inconclusiveand that Avandia is safe and effective, when used according to directions.Glaxo shares initially fell on the news, but later rose to close at $37.90, up1.6 percent.

[font=SimSun]葛兰素史克药厂在一项声明中表示，它们不相信[/font]Avandia[font=SimSun]引起肝衰竭，同时表示它们的数据显示在所提及的肝脏问题中，该药有良好的安全记录。该公司表示，在心脏病的资料是不确定的，如果依指示服药，[/font]Avandia[font=SimSun]是安全而有效的。葛兰素史克药厂的股价在新闻出现的一开时始出现滑落，但稍后扬升到接近[/font]$37.90[font=SimSun]，上升[/font]1.6[font=SimSun]个百分点。[/font]

[font=SimSun]资料来源：[/font][url=http://www.diabetes.org/diabetesnewsarticle.jsp?storyId=18773015&filename=20081030/ap20081030aponlineallD94522HG1newsaporganpaewEDIT.xml][font=SimSun]消费者团体建议禁用[/font]Avandia[/url]

:ops 小柱老师，“Avandia”这种药在国内叫什么？或者在国内类似的药是什么呢？

文迪雅吧

这就是常说的，罗格列酮－Rosiglitazone。

胰岛素增敏剂，用来增加身体对胰岛素的敏感程度，目前在台湾，除非适应症明确，否则并不建议作为第1线的用药。而第1型不能用。

[quote]原帖由 [i]唐校长[/i] 于 2008-11-4 10:55 发表 [url=http://bbs.tnbzy.com/redirect.php?goto=findpost&pid=99051&ptid=21788][img]http://bbs.tnbzy.com/images/common/back.gif[/img][/url]
文迪雅吧 [/quote]

没错。

看来一切都在“摸索中”